MOTS-C nothing more. nothing less.
MOTS-c is a mitochondrial-derived peptide encoded within the 12S rRNA region. Studied in research involving mitochondrial signaling, AMPK activation, metabolic stress response, and cellular energetics.
Purity >99%Form Lyophilized PowderNo Endotoxins
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For research use only — not for human consumption, therapeutic, or diagnostic use. By adding to cart you acknowledge these terms.
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About This Compound
Deep technical insights for clinical research
Synthesis & Purity Overview
Form: Lyophilized powder
Storage: −20°C, desiccated
Reconstitution: Bacteriostatic water
Related Research
Intra-batch variance below 0.15% across peptide identity, purity, and AMPK activation assays.
Zero detection of heavy metals, endotoxins, residual solvents, and microbial contamination.
Chemical Architecture
C₁₀₁H₁₅₂N₂₈O₂₂S₂
2174.64 g/mol
1627580-64-6
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Primary Research Applications
This compound is supplied strictly for in-vitro and preclinical research use only. Primary applications include the areas below.
Activates AMPK pathway to enhance mitochondrial biogenesis and restore metabolic homeostasis in insulin resistance models.
Reverses age-dependent insulin resistance and obesity through preservation of metabolic flexibility and mitochondrial respiration.
Research Community Feedback
"Consistency is paramount in our cellular model testing. Blank's peptides have maintained the tightest purity specs of any RUO vendor we've audited."
Dr. Julian Kessler
Lead Investigator, Biomatrix Labs
"The availability of detailed MS and HPLC data on the product page saved us two days of redundant internal verification. Professional grade synthesis."
Anika S. Singh
Synthetics Quality Control
"Finally, a supplier that doesn't hide behind consumer marketing. Stark, clear, and high-purity. Exactly what a modern lab needs."
Prof. David Emmerich
Applied Peptide Research
Peer-Reviewed Literature
Related Studies
MOTS-c Is an Exercise-Induced Mitochondrial-Encoded Regulator of Age-Dependent Physical Decline and Muscle Homeostasis
Nature Communications
MOTS-c enhanced physical performance across the lifespan; in aged mice (equivalent to 65+ years), it doubled running capacity by regulating nuclear gene expression in skeletal muscle.
The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance
Cell Metabolism
Foundational study identifying MOTS-c as a novel mitochondrial-derived peptide that prevents age- and diet-induced insulin resistance through AMPK activation via folate cycle inhibition.
Mitochondrial-Encoded Peptide MOTS-c Prevents Pancreatic Islet Cell Senescence to Delay Diabetes
Experimental & Molecular Medicine
MOTS-c reduced senescence markers in aged pancreatic islets and improved glucose intolerance in diabetic mice. Circulating MOTS-c levels are lower in T2D patients versus healthy controls.
MOTS-c Is an Exercise-Induced Mitochondrial-Encoded Regulator of Age-Dependent Physical Decline and Muscle Homeostasis
Nature Communications
MOTS-c levels increase with exercise, and exogenous MOTS-c administration in aged mice improved physical capacity, grip strength, gait, and thermogenesis to levels approximating young controls.
MOTS-c Peptide Regulates Adipose Homeostasis to Prevent Ovariectomy-Induced Metabolic Dysfunction
Journal of Molecular Medicine
MOTS-c treatment prevented ovariectomy-induced obesity and insulin resistance by promoting brown adipose tissue activation, improving glucose tolerance, and reducing visceral fat accumulation.
The Mitochondrial-Derived Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress
Cell Metabolism
MOTS-c translocates to the nucleus under metabolic stress to directly regulate ARE-containing genes via AMPK-dependent chromatin remodeling — establishing a novel mito-nuclear communication pathway.
From the Lab
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