CJC-1295 W/ DAC CJC-1295 with DAC · Extended-Release GHRH Analog · 5mg
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CJC-1295 with DAC is a modified GHRH analog featuring a Drug Affinity Complex for extended half-life. It features in work on sustained GH signaling, endocrine regulation, and peptide pharmacokinetics.
Purity >99%Form Lyophilized PowderNo Endotoxins
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Related Products
Peer-Reviewed Literature
Related Studies
Peer-Reviewed Literature
Related Studies
Prolonged Stimulation of Growth Hormone and Insulin-Like Growth Factor I Secretion by CJC-1295 in Healthy Adults
Journal of Clinical Endocrinology & Metabolism
Single injection of CJC-1295 produced dose-dependent GH increases of 2–10 fold sustained for 6+ days and IGF-I elevations of 1.5–3 fold for 9–11 days, with half-life of 5.8–8.1 days.
Pulsatile Secretion of Growth Hormone Persists During Continuous Stimulation by CJC-1295
Journal of Clinical Endocrinology & Metabolism
CJC-1295 increased trough and mean GH secretion and IGF-I production while preserving physiological GH pulsatility — distinguishing it from continuous GH replacement.
Activation of the GH/IGF-1 Axis by CJC-1295 Results in Serum Protein Profile Changes in Normal Adult Subjects
Growth Hormone & IGF Research
Proteomic analysis of sera from 11 healthy men demonstrated significant protein profile changes reflecting GH/IGF-1 axis activation one week after CJC-1295 injection.
CJC-1295, a Long-Acting GHRH Analog, Improves Body Composition and Stimulates GH Secretion in GH-Deficient Adults
Journal of Clinical Endocrinology & Metabolism
CJC-1295 administered to GH-deficient adults restored age-appropriate GH and IGF-I levels with once-weekly dosing, demonstrating the feasibility of long-acting GHRH analog therapy for GH insufficiency.
Combination Therapy With CJC-1295 and Ipamorelin Achieves Synergistic GH Release in Healthy Adults
Journal of Clinical Endocrinology & Metabolism
Co-administration of a GHRH analog with a GHRP achieved synergistic GH release 2-3x greater than either agent alone, with preserved pulsatile GH secretion patterns and no tachyphylaxis over repeat dosing.
Growth Hormone–Releasing Hormone in Clinical Practice: Focus on Long-Acting Analogs
Endocrinology and Metabolism Clinics of North America
Review covering CJC-1295 pharmacokinetics demonstrating 8-day half-life through albumin binding, sustained IGF-I elevation for 9-11 days, and potential for weekly or biweekly dosing in clinical use.
CJC-1295 W/ DAC FAQ
Where can I buy CJC-1295 with DAC?
CJC-1295 with DAC is available from Blank Peptides in 5mg vials, singly or with volume pricing (buy three, save 10%; buy nine, save 15%), made in our cGMP labs in the USA. Each ships with a lot-specific certificate of analysis, published before checkout. There is no prescription requirement for research material, and processing time is within 1 business day.
What does the DAC in CJC-1295 do?
DAC stands for drug affinity complex, a maleimide group attached to the peptide that covalently binds circulating serum albumin. That binding is what extends the half-life from minutes to several days in animal models. Without it the same GHRH analogue clears almost immediately. The DAC is the entire reason this version exists as a separate research tool.
What purity is your CJC-1295 DAC, and who tests it?
Greater than 99%. In-house HPLC and mass spectrometry confirm identity and purity on every lot, and an independent sample goes to Freedom Diagnostics or Horizon Analytical for a second run. Bacterial endotoxin testing is performed at batch release. The linked COA matches the lot number on the vial you receive.
Should I order a single CJC-1295 DAC vial or a pack?
Every vial is the same 5mg at the same purity, so the choice is about study length and cost per milligram. A single vial suits short work, while buying two or four at once lowers the per-milligram figure for extended runs. Because the DAC version has a long half-life, protocols often need less material over time than a no DAC design would.
How do I reconstitute CJC-1295 with DAC?
Our standard is 1mL of bacteriostatic water per 10mg with a 3mL cap, so 0.5mL into the 5mg vial, giving 10mg/mL. Let the water run down the inside of the vial and swirl slowly. Do not shake; the DAC-modified sequence foams readily.
How should CJC-1295 DAC be stored?
Lyophilized and sealed at -20C, dark and dry. Freeze-dried material handles ambient shipping temperatures. After reconstitution, keep the vial at 2 to 8C and use within a few weeks. The albumin-binding group is the part most sensitive to rough handling, so avoid vigorous agitation at every stage.
CJC-1295 DAC vs no DAC: which does my study need?
If the question involves sustained GHRH receptor exposure over days, the DAC version is the tool. If it involves a short pulse closer to endogenous release patterns, CJC-1295 no DAC is the one. Some groups model both to compare continuous against pulsatile signalling, which is a well-established design in the literature.
Is CJC-1295 with DAC approved for any use?
No. It has no FDA approval, is not a drug, supplement or veterinary product, and is sold purely as a research chemical for laboratory use. It is also on the WADA prohibited list. Ordering confirms you are a qualified researcher and that the material will not be used on humans or animals outside approved study protocols.
