KPV
KPV is a naturally occurring tripeptide derived from alpha-melanocyte stimulating hormone (α-MSH). Researchers examine melanocortin pathway activity, inflammatory modulation, and mucosal signaling.
Purity >99%Form Lyophilized PowderNo Endotoxins
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Peer-Reviewed Literature
Related Studies
Peer-Reviewed Literature
Related Studies
PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation
Gastroenterology
KPV inhibits NF-κB activation and pro-inflammatory cytokine secretion through PepT1 transporter mechanism. Oral administration reduced DSS- and TNBS-induced colitis incidence.
Melanocortin-Derived Tripeptide KPV Has Anti-Inflammatory Potential in Murine Models of Inflammatory Bowel Disease
Inflammatory Bowel Diseases
KPV demonstrated earlier recovery, stronger body weight regain, and significantly reduced inflammatory infiltrates in two IBD models, with effects partially independent of MC1R signaling.
Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis
Molecular Therapy
HA-KPV nanoparticles showed targeted delivery to colonic epithelial cells and macrophages, exerting combined effects against UC by accelerating mucosal healing and alleviating inflammation.
KPV Nanoparticles Effectively Treat Inflammatory Bowel Disease in Mice Through Oral Delivery
Journal of Controlled Release
KPV-loaded nanoparticles delivered orally showed significant anti-inflammatory efficacy in DSS-induced colitis models, reducing TNF-α and IL-6 while maintaining mucosal integrity, rivaling corticosteroid effects.
Anti-Inflammatory Effects of α-MSH Through p53-Mediated NF-κB Activation in Human Melanocytes
Journal of Biological Chemistry
KPV (C-terminal tripeptide of α-MSH) inhibited NF-κB translocation and downstream pro-inflammatory gene expression through a melanocortin receptor-independent mechanism, demonstrating direct intracellular anti-inflammatory action.
α-MSH Tripeptide Analogs Activate the Melanocortin MC1 Receptor and Reduce Mucosal Damage in Experimental Colitis
PLoS One
Systemic KPV administration reduced disease activity index, prevented colonic shortening, and preserved mucosal architecture in acute colitis models through MC1R-mediated and NF-κB-independent pathways.
KPV FAQ
Where is KPV peptide for sale?
KPV is available from Blank Peptides in 10mg vials, manufactured in our cGMP labs in the USA. Each vial ships with a lot-matched certificate of analysis you can open before you buy. We sell to researchers directly, no prescription and no waiting list, with a processing time within 1 business day.
What is KPV peptide?
KPV is a tripeptide made of lysine, proline and valine, corresponding to the C-terminal fragment of alpha-MSH. It carries the anti-inflammatory portion of the parent hormone without the melanocortin receptor binding that drives pigmentation. Published research covers colitis models in rodents, epithelial barrier work, and NF-kB pathway signalling in cell culture.
Is your KPV third-party tested?
Yes. Purity is greater than 99%, established by our own HPLC and mass spec work and confirmed by an independent run at Freedom Diagnostics or Horizon Analytical. Every batch also goes through bacterial endotoxin testing before it is released. The linked COA carries the same lot number printed on your vial.
How do I reconstitute KPV 10mg?
1mL of bacteriostatic water into the 10mg vial, giving 10mg/mL, which is our standard ratio across the catalogue. Introduce the water against the glass rather than straight into the cake and swirl rather than shake. KPV is a short tripeptide and typically dissolves quickly, often within seconds of contact.
How should KPV be stored after it arrives?
Keep the sealed vial lyophilized at -20C, dark and dry, until you need it. Transit at ambient temperature does no harm. Reconstituted KPV goes in the fridge at 2 to 8C and should be used within a few weeks. Avoid cycling the solution in and out of the freezer, which degrades short peptides faster than people expect.
KPV vs BPC-157: do they overlap?
Only loosely. KPV research runs through melanocortin-derived anti-inflammatory signalling, while BPC-157 work sits in growth factor and angiogenic pathways. Groups modelling both mechanisms together generally reach for KLOW, the four-peptide blend that includes KPV alongside BPC-157, TB-500 and GHK-Cu.
How quickly do KPV orders ship?
Processing time is within 1 business day, and Blank Peptides ships from inside the USA in unmarked outer packaging. Tracking is emailed once the label prints. Vials go out padded, and multi-vial packs travel together in a single box. Damaged glass on arrival gets replaced once we see photos.
Can KPV be bought without a prescription?
Yes, because it is sold as a research chemical rather than a medicine. KPV holds no FDA approval, is not a drug or supplement, and is not intended for human or veterinary use. Ordering it confirms the material stays in a laboratory setting and that you are handling it as a qualified researcher.