MELANOTAN 2 nothing more. nothing less.
Melanotan II is a synthetic analog of alpha-melanocyte stimulating hormone (α-MSH). Studied in research involving melanocortin receptor binding, pigmentation pathways, and neuroendocrine signaling.
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For research use only — not for human consumption, therapeutic, or diagnostic use. By adding to cart you acknowledge these terms.
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About This Compound
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Primary Research Applications
This compound is supplied strictly for in-vitro and preclinical research use only. Primary applications include the areas below.
Selectively activates MC1R on melanocytes to promote eumelanin synthesis and skin darkening without UV exposure.
Serves as a non-selective melanocortin receptor agonist for studying MC1R, MC3R, MC4R, and MC5R pathway interactions.
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Peer-Reviewed Literature
Related Studies
Melanocortin Receptor Agonists, Penile Erection, and Sexual Motivation: Human Studies with Melanotan II
International Journal of Impotence Research
Double-blind crossover study in 20 men found MT-II induced erection in 17/20 subjects without sexual stimulation, with 68% reporting increased sexual desire versus 19% on placebo.
Effect of Melanotan [Nle4, D-Phe7]-α-MSH on Melanin Synthesis in Humans with MC1R Variant Alleles
Peptides
77 Caucasian participants showed significant melanin density increase (p<0.001) versus placebo. Greater effect observed in subjects with MC1R variant alleles compared to wild-type.
An Overview of Benefits and Risks of Chronic Melanocortin-1 Receptor Activation
Journal of the European Academy of Dermatology and Venereology
Comprehensive 2025 review examining melanogenesis mechanisms, safety profile, and clinical utility of melanocortin receptor activation in dermatological research applications.
Subcutaneous Melanotan II for the Treatment of Sexual Dysfunction in Premenopausal Women
Journal of Sexual Medicine
RCT in 18 premenopausal women with female sexual arousal disorder demonstrated Melanotan II significantly increased genital arousal, sexual desire, and sexual satisfaction versus placebo.
Superpotent α-Melanotropin Analogs: Biological Activities and Melanogenesis in Murine Melanoma Cells
Molecular and Cellular Endocrinology
Original characterization of Melanotan II demonstrating 100-1000x greater melanotropic potency than native α-MSH, prolonged biological activity, and high resistance to enzymatic degradation.
Effect of Melanotan-II on Penile Erection in Men with Psychogenic Erectile Dysfunction: Dose-Response
Journal of Urology
Subcutaneous Melanotan II produced clinically meaningful erectile responses in 17 of 20 men with psychogenic ED, with a dose-dependent increase in penile rigidity across multiple monitoring parameters.
From the Lab
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