TB-500 TB-500 Research Peptide · Thymosin Beta-4 · 10mg
TB-500 is a synthetic analog of thymosin beta-4, a naturally occurring 43-amino-acid peptide involved in cell migration and cytoskeletal regulation. It is studied in wound healing, inflammatory response, and tissue remodeling models.
Purity >99%Form Lyophilized PowderNo Endotoxins
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Peer-Reviewed Literature
Related Studies
Peer-Reviewed Literature
Related Studies
Thymosin β4 Activates Integrin-Linked Kinase and Promotes Cardiac Cell Migration, Survival and Cardiac Repair
Nature
Thymosin β4 activated epicardial progenitor cells, inhibited myocardial cell death, stimulated vessel growth, and reduced cardiac scarring through integrin-linked kinase activation.
Thymosin β4 Induces Adult Epicardial Progenitor Mobilization and Neovascularization
Nature
Thymosin β4 activated quiescent epicardial cells, promoting their migration into cardiac tissue where they facilitate coronary neovascularization and regeneration of functional myocardium.
Thymosin Beta 4 Ophthalmic Solution for Dry Eye: A Randomized, Placebo-Controlled, Phase II Clinical Trial
Clinical Ophthalmology
RGN-259 (thymosin β4) showed significant reduction in discomfort scores and improvements in corneal staining in 72 subjects with dry eye disease.
RGN-259 (Thymosin β4) Improves Clinically Important Dry Eye Efficacies in Comparison with Prescription Drugs
Scientific Reports
Thymosin β4 proved equal to or more effective than cyclosporine A, diquafosol, and lifitegrast in promoting mucin recovery, corneal integrity, and reducing inflammation.
Thymosin β4: A Multi-Functional Regenerative Peptide. Basic Properties and Clinical Applications
Expert Opinion on Biological Therapy
Comprehensive review spanning three decades of Tβ4 research documenting its roles in wound healing, anti-inflammation, angiogenesis, and cardiac repair with a focus on translational clinical applications.
Thymosin Beta 4 Promotes Dermal Wound Healing via Its Anti-Inflammatory and Tissue-Regenerative Activities
Journal of Investigative Dermatology
Topical and systemic Tβ4 application accelerated dermal wound healing in aged mice, with enhanced angiogenesis, collagen deposition, and keratinocyte migration compared to controls.
TB-500 FAQ
Where is TB 500 for sale online?
You can buy TB 500 from Blank Peptides in 10mg vials, singly or in 2-packs and 4-packs, all made in our cGMP labs in the USA. Every vial carries a lot-matched COA you can read before checkout rather than after. We sell to researchers without a prescription requirement or an approval queue, and orders have a processing time within 1 business day.
What is the TB-500 peptide?
TB-500 is a synthetic fragment of thymosin beta-4, the actin-sequestering peptide found in most mammalian tissue. Published research has looked at its actin-binding domain in cell migration assays, corneal and dermal wound models in rodents, and cardiac tissue studies. The compound is supplied for those kinds of laboratory investigations and nothing else.
What purity is your TB-500?
Greater than 99%, confirmed twice. Our own HPLC and mass spec run happens at the lab, and an independent sample goes to Freedom Diagnostics or Horizon Analytical for a second opinion. Bacterial endotoxin testing is part of every batch release. Both sets of numbers show up on the COA we publish for your specific lot.
How do I reconstitute TB-500 10mg?
Add 1mL of bacteriostatic water to the 10mg vial for a 10mg/mL solution, our standard 1mL per 10mg ratio. Point the needle at the glass wall, let the water run down rather than jetting into the powder, then rotate the vial slowly. The cake should dissolve in under a minute.
What is the shelf life of lyophilized TB-500?
Kept sealed, dark and at -20C, the lyophilized powder is stable for a long stretch, which is why peptides ship freeze-dried rather than premixed. Ambient temperature during transit does not harm it. After reconstitution, store at 2 to 8C, keep the stopper clean, and plan on using the solution within a few weeks.
TB-500 vs BPC-157 for tissue research?
Different mechanisms, different literature. TB-500 work is built around actin sequestration and cell migration, while BPC-157 studies focus on growth factor and angiogenic signalling. Because the two are often modelled together, the Wolverine blend puts both in one vial at a fixed ratio, which saves a reconstitution step.
How is TB-500 shipped?
Blank Peptides ships from inside the USA in discreet outer packaging, with processing time within 1 business day. Vials go out padded and insulated against knocks rather than temperature, since lyophilized peptide travels fine at ambient. Tracking arrives by email. Damaged glass or a disturbed cake gets replaced; send photos to support.
Is TB-500 approved for human use?
No. TB-500 has no FDA approval, is not a drug or supplement, and is sold strictly as a research chemical for laboratory use. It is also on the WADA prohibited list, which matters if you work anywhere near sport testing. Buying it means the material stays in a research setting.