EPITHALON nothing more. nothing less.
Epithalon is a synthetic tetrapeptide based on the naturally occurring epithalamin from the pineal gland. Studied in research involving telomerase activation, circadian regulation, and cellular senescence pathways.
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About This Compound
Deep technical insights for clinical research
Primary Research Applications
This compound is supplied strictly for in-vitro and preclinical research use only. Primary applications include the areas below.
Activates telomerase enzyme and extends telomere length in somatic cells, exceeding the Hayflick limit in vitro.
Extends lifespan in animal models and improves telomere length through pineal peptide bioregulation.
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Applied Peptide Research
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Pairs & Supplies
The compounds and tools researchers stack with EPITHALON.
Peer-Reviewed Literature
Related Studies
Epitalon Increases Telomere Length in Human Cell Lines Through Telomerase Upregulation or ALT Activity
Biogerontology
Epitalon induced telomerase activity and extended telomere length across multiple human cell lines, with cells exceeding the Hayflick limit by approximately 10 passages. Animal studies showed 12–13% lifespan increase.
Overview of Epitalon — Highly Bioactive Pineal Tetrapeptide with Promising Properties
International Journal of Molecular Sciences
Comprehensive review detailing 25 years of epitalon research including telomerase activation mechanisms, methylated DNA binding, histone H1 interaction, and epigenetic regulation of gene expression.
AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis During Neurogenesis: Possible Epigenetic Mechanism
Journal of Molecular Neuroscience
Epitalon stimulated gene expression and protein synthesis during neurogenesis through epigenetic mechanisms involving methylated DNA binding and histone protein interactions.
Peptide Regulation of Gene Expression and Protein Synthesis in Bronchial Epithelium
Lung
Epithalon and related peptide bioregulators activated specific gene expression in aging human bronchial epithelial cells, restoring signal transduction and proliferative capacity to levels seen in younger cells.
Peptides, Genome, Epigenetics
Advances in Gerontology
Epitalon and short peptides interact directly with DNA through complementary nucleotide binding, modulating chromatin structure and gene expression — providing an epigenetic mechanism for peptide bioregulation.
Effect of the Pineal Gland Peptide Preparation Epithalamin on the Lifespan and Spontaneous Tumour Incidence in Female SHR Mice
Mechanisms of Ageing and Development
Epithalamin treatment begun in old age increased mean lifespan of female SHR mice by 12.3%, reduced spontaneous tumour incidence, and inhibited tumour growth rate — extending maximum lifespan.
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