(4-Pack) NAD+ – 500mg
Related Products
Peer-Reviewed Literature
Related Studies
Peer-Reviewed Literature
Related Studies
NAD+ Metabolism and Its Roles in Cellular Processes During Ageing
Nature Reviews Molecular Cell Biology
Seminal review examining NAD+ as a central redox cofactor in 500+ enzymatic reactions, detailing how age-related NAD+ decline drives senescence, genomic instability, and metabolic dysfunction.
NAD+ Metabolism in Cardiac Health, Aging, and Disease
Circulation
NAD+ pools decline with aging, obesity, and hypertension. Experimental NAD+ elevation improves multiple cardiomyopathies and extends healthspan in preclinical models.
NR-SAFE: A Randomized, Double-Blind Safety Trial of High Dose Nicotinamide Riboside in Parkinson's Disease
Nature Communications
High-dose nicotinamide riboside (3,000 mg daily) was safe and well-tolerated, producing up to 5-fold blood NAD+ increases with improvement in motor scores correlating with NAD+ response.
Cellular NAD Replenishment Confers Marked Neuroprotection Against Ischemic Cell Death
Stroke
NAD+ supplementation conferred robust neuroprotection against oxygen-glucose deprivation-induced cell death through enhanced DNA repair capacity and reduced cytotoxic DNA lesions.
Chronic Nicotinamide Riboside Supplementation Is Well-Tolerated and Elevates NAD+ in Healthy Middle-Aged and Older Adults
Nature Communications
First-in-human crossover study demonstrated that 6-week NR supplementation raised whole-blood NAD+ by 60%, was well-tolerated, and showed trends toward reduced arterial stiffness and lowered systolic blood pressure.
NAD+ Repletion Rescues Female Fertility During Reproductive Aging
Cell Reports
NAD+ precursor treatment in aged mice restored oocyte quality, improved ovulation rates, and rescued fertility to levels comparable to young controls — implicating NAD+ decline in age-related infertility.