NAD+ NAD+ · Research Grade · 500mg / 1000mg
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme essential to cellular energy metabolism and redox reactions. Research interest sits in sirtuin activation, mitochondrial function, and DNA repair signaling.
Purity >99%Form Lyophilized CompoundNo Endotoxins
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Related Products
Peer-Reviewed Literature
Related Studies
Peer-Reviewed Literature
Related Studies
NAD+ Metabolism and Its Roles in Cellular Processes During Ageing
Nature Reviews Molecular Cell Biology
Seminal review examining NAD+ as a central redox cofactor in 500+ enzymatic reactions, detailing how age-related NAD+ decline drives senescence, genomic instability, and metabolic dysfunction.
NAD+ Metabolism in Cardiac Health, Aging, and Disease
Circulation
NAD+ pools decline with aging, obesity, and hypertension. Experimental NAD+ elevation improves multiple cardiomyopathies and extends healthspan in preclinical models.
NR-SAFE: A Randomized, Double-Blind Safety Trial of High Dose Nicotinamide Riboside in Parkinson's Disease
Nature Communications
High-dose nicotinamide riboside (3,000 mg daily) was safe and well-tolerated, producing up to 5-fold blood NAD+ increases with improvement in motor scores correlating with NAD+ response.
Cellular NAD Replenishment Confers Marked Neuroprotection Against Ischemic Cell Death
Stroke
NAD+ supplementation conferred robust neuroprotection against oxygen-glucose deprivation-induced cell death through enhanced DNA repair capacity and reduced cytotoxic DNA lesions.
Chronic Nicotinamide Riboside Supplementation Is Well-Tolerated and Elevates NAD+ in Healthy Middle-Aged and Older Adults
Nature Communications
First-in-human crossover study demonstrated that 6-week NR supplementation raised whole-blood NAD+ by 60%, was well-tolerated, and showed trends toward reduced arterial stiffness and lowered systolic blood pressure.
NAD+ Repletion Rescues Female Fertility During Reproductive Aging
Cell Reports
NAD+ precursor treatment in aged mice restored oocyte quality, improved ovulation rates, and rescued fertility to levels comparable to young controls — implicating NAD+ decline in age-related infertility.
NAD+ FAQ
Where can I buy NAD+ peptide for research?
Blank Peptides sells NAD+ in 500mg and 1000mg vials, produced in our cGMP labs in the USA. Plenty of people shop for it as a peptide and it sits on the same shelf, though chemically it is a dinucleotide coenzyme. Each vial ships with a certificate of analysis matched to its lot and readable before checkout. Processing time is within 1 business day.
What is NAD+?
NAD+, nicotinamide adenine dinucleotide, is a coenzyme present in every living cell and central to redox reactions and cellular energy metabolism. It is a dinucleotide rather than a peptide, which is worth knowing before you order. Research interest sits in sirtuin activation, mitochondrial function and DNA repair signalling.
What purity is your NAD+, and who verifies it?
Greater than 99%. Identity and purity are established by HPLC and mass spectrometry in our own laboratory, then confirmed by an independent run at Freedom Diagnostics or Horizon Analytical. Bacterial endotoxin testing is performed on every batch before release, and the lot-specific certificate is published for you to read.
How do I reconstitute NAD+ 500mg or 1000mg?
NAD+ is one of two exceptions to our 1mL per 10mg standard, because the mass involved makes that ratio impractical. Larger solvent volumes are used instead. A common laboratory approach is 5mL of bacteriostatic water into a 500mg vial and 10mL into a 1000mg vial, both giving 100mg/mL. Add the water slowly and swirl.
Why does NAD+ come in 500mg and 1000mg when peptides come in 10mg?
Because it is a coenzyme, not a signalling peptide, and research protocols work at a completely different scale. Milligram-per-vial figures across our peptide catalogue reflect receptor-level pharmacology. NAD+ work is metabolic and uses far more material, which is why the vial sizes and the reconstitution volumes both jump by two orders of magnitude.
How should NAD+ be stored?
Sealed lyophilized vials at -20C, dark and dry. NAD+ is hygroscopic, so keeping moisture out matters more here than with most of the catalogue. Once reconstituted, keep it refrigerated at 2 to 8C, protect from light, and use within a short window. NAD+ in solution is less stable than lyophilized powder by a wide margin.
NAD+ vs glutathione for cellular research?
Different chemistry and different roles. NAD+ is a dinucleotide coenzyme that drives redox reactions and feeds sirtuin activity. Glutathione is a tripeptide that acts as the cell's main antioxidant buffer. Both are high-mass, non-peptide-style SKUs in our range, and studies of oxidative and metabolic stress often involve both.
How is NAD+ shipped, and is it legal to buy?
It ships from inside the USA in plain outer packaging with a processing time within 1 business day. NAD+ is supplied as a research chemical for laboratory use, not as a drug, supplement or veterinary product, and this material holds no FDA approval. Ordering confirms qualified research use only.